Here you will find descriptive information about the section of Module Values.

• Module values: You can download the matrix of module activity values by clicking on Module Values.
• Heatmap: A heatmap is a graphical representation of the values of a matrix. A not-supervised clustering is performed on the data per columns (samples). A good separation between the two colors of the upper bar of the heatmap indicates that the differences between the two groups are big enough to discriminate between them.
• PCA: A Principal Components Analysis is performed in order to see if the matrix contains information enough to separate between the two groups.
• Module significance: Ordered table of module significance. More significant module are displayed in the upper part of the table. For each circuit, the following information is shown:
  • ModuleID: This code is identifying the KEGG module ID and the metabolite which produced (last node of module) by the module (e.g M00036_C00164). If module is a loop like TCA cycle, a random node of the module is used as last node of module (M00009_R00342,R00361).
  • ModuleDescription: Description of the module.
  • Pathway: Name of the pathway which contains module.
  • statistic: Statistic of the Wilcoxon test performed between conditions.
  • p.value: P-value of the statistic test.
  • adj.pvalue: Adjusted p-value of the statistic test using the FDR method.
  • Status: Up when the module is up-regulated in the disease case, DOWN otherwise.
  • StartMetaboliteID: First node(s) of the module. Node(s)with zero indegree. KEGG metabolite ID.
  • StartMetaboliteName: First node(s) of the module. Node(s)with zero indegree. KEGG metabolite name.
  • StartMetaboliteID: First node(s) of the module. Node(s)with zero indegree. KEGG metabolite ID.
  • StartMetaboliteName: First node(s) of the module. Node(s)with zero indegree. KEGG metabolite name.
  • EndMetaboliteID: Last node of the module. Node with zero outdegree. KEGG metabolite ID.
  • EndMetaboliteName: Last node of the module. Node with zero outdegree. KEGG metabolite name.
  • KEGGlink: Link of the module on http://www.genome.jp/kegg/module.html