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Table of Contents
Differential signaling
HiPathia allows us to compute a signal value for each signaling path and each one of our data samples. Therefore, it allows us to compare the signal value between different conditions.
The tools can be accessed from the main menu bar, by clicking on the button Differential signaling (see Workflow).
The main page of a the tool is its filling in form. This form includes all the information and parameters that the tool needs to process a job. The form is divided in different panels:
Input data
In the input data panel, we must introduce the expression data and, optionally, the variant data.
The expression data can be either an:
- Expression matrix provided by yourself (see how to upload files in Upload your data), or
- Expression vector taken from an expression database. In this case, we must choose the tissue database and tissue names.
The variant data must be a VCF file.
Design data
The design data panel allows you to choose the kind of experiment you want to perform. You can choose between two main experimental designs:
- Two group comparison:
- Correlation with continuous variable: