Differences

This shows you the differences between two versions of the page.

--- what_can_do_hipathia_for_you [2016/12/26 13:17] – [Prediction] ccubuk
+++ what_can_do_hipathia_for_you [2017/05/24 14:33] (current) – external edit 127.0.0.1
@@ Line 23: / Line 23: @@
 Metabolizer-Knockout allows you to modify the expression value of a set of genes and then check the effect of this change at the level of module activity. In this way, you can simulate effect of knockouts (KO) and over-expressions of one or several genes or the effect of drug(s) in the activity of metabolic modules.
 The simulations can be done:
-  * Using single sample. This option calculates fold-change of module activity between after and before KO/OE.
+  * Using single sample: This option calculates fold-change of module activity between after and before KO/OE.
-  * Using multiple samples. This option uses one selected sample to calculate effect of in-silico intervention of gene expression on module activity. Rest of the samples are used to train a prediction model. Metabolizer uses this trained model to calculate class probability of selected sample including before and after intervention.
+  * Using multiple samples: This option uses one selected sample to calculate effect of in-silico intervention of gene expression on module activity. Rest of the samples are used to train a prediction model. Metabolizer uses this trained model to calculate class probability of selected sample including before and after intervention.
-  * User can use the options below by selecting single/multiple genes or drug(s) on interactive pathway panel. Metabolizer also allows to auto-KOs. Selecting auto KOs calculates effect of simple KOs using all module genes by one by.
+  * User can use the options above by selecting single/multiple genes or drug(s) on interactive pathway panel. Metabolizer also allows to auto-KOs. Auto-KOs option calculates effect of simple KOs using all module genes by one by.
 In order to check how to use these options please see [[in-silico_knockout:over_expression| Knockout]].